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The intercellular spacedistends because of the accumulating fluid moving across theepithelium but it can distend only to a limited degree becauseofjunctional attachments in the apical and basal portions ofthecell. In probabilistic riskassessment, input variables are entered as probability densityfunctions (PDFs) instead of single values

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amiodarone in restoration and maintenance of sinusrhythm in patients with persistent AF, randomized 665 patientsto sotalol (n = 261), amiodarone (n = 261), and placebo (n = 137)who were followed for 1–4.5 years with weekly monitoring.

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